English
SlovenčinaDepartment of Clinical Research
Research Topic
The Department of Clinical Research (OKV) is focused on the research of the processes involved in the initiation and development of autoimmune, cardiovascular and metabolic diseases. The Department is a continuation of the Laboratory of Human Endocrinology of the Institute of Experimental Endocrinology. In the past, the research has focused mainly on stress research and on altered regulation of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system in patients with autoimmune diseases (e.g. rheumatoid arthritis). Another research areas were blood pressure regulation and glucose metabolism in patients with hypertension and obesity.
OKV research is currently focused on the metabolic, neuroendocrine and cardiovascular aspects of multiple sclerosis, obesity and metabolic syndrome.
At present, OKV research focuses on three main areas, namely:
(1) Pathophysiological mechanisms inducing insulin resistance in patients with newly diagnosed multiple sclerosis. Changes in regulation of carbohydrate metabolism and sympathetic nervous system are studied. In addition, changes in endothelial injury parameters as well as metabolism of brain and muscle tissue are monitored. The possible therapeutic effect of improving the glucose metabolism is currently researched.
(2) Obesity and metabolic syndrome and mechanisms of regulation of body weight and energy expenditure in overweight and obese patients. The effect of intensive diet-induced lifestyle changes and exercise on carbohydrate and lipid metabolism as well as changes in myokines and adipokines levels, hepatic and thyroid parameters are studied.
(3) Changes in humoral communication via cytokines and activation of T lymphocytes and monocytes in patients with autoimmune diseases (rheumatoid arthritis, multiple sclerosis).
Research Team
2001 – 2015 Laboratory of Human Endocrinology, Institute of Experimental Endocrinology SAS, Ph.D. student, scientist, Head of the laboratory
2007 – 2013 Center of Molecular Medicine SAS, scientist, Head of institute
2016 – Institute of Clinical and Translational Research, Biomedical Research Centre SAS, senior scientist
107 WOS publications, 1625 WOS citations, h-index 24
Web of Science ResearcherID: ABC-7247-2021
Main research topics: Neuro-endocrine-immune interactions, sympathetic nervous system, rheumatic diseases, glucose metabolism and insulin resistance
SCIENTIFIC STAFF:
doc. MUDr. Adela Penesová, PhD.
MUDr. Žofia Rádiková, PhD.
MUDr. Miroslav Vlček, PhD.
SCIENTIFIC AND TECHNICAL STAFF:
Mgr. Andrea Havranová
PhD STUDENTS:
MUDr. Zuzana Dean
Effect of physical activity and nutrition on gut microbiota modification in healthy subjects and patients with a non – communicable diseases
2018 – 2022
APVV
Hepatic, lipid and cardiometabolic parameters changes in obese patients
2020 – 2023
VEGA
Effects of GLP-1 Analog on Multiple Sclerosis
2022 – 2026
APVV
Bielik V, Hric I, Ugrayová S, Kubáňová L, Putala M, Grznár Ľ, Penesová A, Havranová A, Šardzíková S, Grendar M, Baranovičová E, Šoltys K, Kolisek M.
Effect of High-intensity Training and Probiotics on Gut Microbiota Diversity in Competitive Swimmers: Randomized Controlled Trial. Sports Med Open. 2022 May 10;8(1):64.
doi: 10.1186/s40798-022-00453-8. PMID: 35536489; PMCID: PMC9091066.
Hardoňová M, Šiarnik P, Siváková M, Suchá M, Vlček M, Imrich R, Turčáni P, Havranová A, Rádiková Ž, Žitňanová I, Dean Z, Penesová A, Kollár B.
Autonomic Nervous System Function in Newly Diagnosed Multiple Sclerosis: Association With Lipid Levels and Insulin Resistance. Physiol Res. 2021 Dec 30;70(6):875-882.
doi: 10.33549/physiolres.934695. Epub 2021 Oct 30. PMID: 34717060; PMCID: PMC8815469.
Imrich R, Vlcek M, Penesova A, Radikova Z, Havranova A, Sivakova M, Siarnik P, Kollar B, Sokolov T, Turcani P, Heckova E, Hangel G, Strasser B, Bogner W.
Cardiac autonomic function in patients with early multiple sclerosis. Clin Auton Res. 2021 Aug;31(4):553-562.
doi: 10.1007/s10286-021-00790-w. Epub 2021 Mar 4. PMID: 33665745.
Ranganath LR, Psarelli EE, Arnoux JB, Braconi D, Briggs M, Bröijersén A, Loftus N, Bygott H, Cox TF, Davison AS, Dillon JP, Fisher M, FitzGerald R, Genovese F, Glasova H, Hall AK, Hughes AT, Hughes JH, Imrich R, Jarvis JC, Khedr M, Laan D, Le Quan Sang KH, Luangrath E, Lukáčová O, Milan AM, Mistry A, Mlynáriková V, Norman BP, Olsson B, Rhodes NP, Rovenský J, Rudebeck M, Santucci A, Shweihdi E, Scott C, Sedláková J, Sireau N, Stančík R, Szamosi J, Taylor S, van Kan C, Vinjamuri S, Vrtíková E, Webb C, West E, Záňová E, Zatkova A, Gallagher JA.
Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2020 Sep;8(9):762-772.
doi: 10.1016/S2213-8587(20)30228-X. Epub 2020 Aug 18. PMID: 32822600.
Hric I, Ugrayová S, Penesová A, Rádiková Ž, Kubáňová L, Šardzíková S, Baranovičová E, Klučár Ľ, Beke G, Grendar M, Kolisek M, Šoltys K, Bielik V.
The Efficacy of Short-Term Weight Loss Programs and Consumption of Natural Probiotic Bryndza Cheese on Gut Microbiota Composition in Women. Nutrients. 2021 May 21;13(6):1753.
doi: 10.3390/nu13061753. PMID: 34064069; PMCID: PMC8224276.
Siarnik P, Penesova A, Radikova Z, Hluchanova A, Hanus O, Klobucnikova K, Turcani P, Kollar B.
Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction. Endocr Regul. 2021 Jan 29;55(1):22-29.
doi: 10.2478/enr-2021-0004. PMID: 33600665.
Rádiková Ž, Penesová A, Vlček M, Havranová A, Siváková M, Šiarnik P, Žitňanová I, Imrich R, Turčáni P, Kollár B.
Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation? Lipids Health Dis.2020 Mar 17;19(1):49.
doi: 10.1186/s12944-020-01221-x. PMID: 32178676; PMCID: PMC7076999.
Sivakova M, Siarnik P, Filippi P, Vlcek M, Imrich R, Turcani P, Zitnanova I, Penesova A, Radikova Z, Kollar B.
Oxidative stress in patients with newly diagnosed multiple sclerosis: any association with subclinical atherosclerosis? Neuro Endocrinol Lett. 2019 Nov;40(3):135-140.
PMID: 31816220.
Bajer B, Rádiková Ž, Havranová A, Žitňanová I, Vlček M, Imrich R, Sabaka P, Bendžala M, Penesová A.
Effect of 8-weeks intensive lifestyle intervention on LDL and HDL subfractions. Obes Res Clin Pract. 2019 Nov-Dec;13(6):586-593.
doi: 10.1016/j.orcp.2019.10.010. Epub 2019 Dec 2. PMID: 31806470.
Ranganath LR, Milan AM, Hughes AT, Khedr M, Davison AS, Shweihdi E, Norman BP, Hughes JH, Bygott H, Luangrath E, Fitzgerald R, Psarelli EE, van Kan C, Laan D, Olsson B, Rudebeck M, Mankowitz L, Sireau N, Arnoux JB, Le Quan Sang KH, Jarvis JC, Genovese F, Braconi D, Santucci A, Zatkova A, Glasova H, Stančík R, Imrich R, Rhodes NP, Gallagher JA.
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. J Inherit Metab Dis. 2020 Jul;43(4):737-747.
doi: 10.1002/jimd.12181. Epub 2020 Feb 5. PMID: 31609457.
Radikova Z, Penesova A, Vlcek M, Havranova A, Sivakova M, Siarnik P, Zitnanova I, Imrich R, Kollar B, Turcani P.
LDL and HDL lipoprotein subfractions in multiple sclerosis patients with decreased insulin sensitivity. Endocr Regul. 2018 Jul 1;52(3):139-145.
doi: 10.2478/enr-2018-0017. PMID: 31517604.
Braconi D, Giustarini D, Marzocchi B, Peruzzi L, Margollicci M, Rossi R, Bernardini G, Millucci L, Gallagher JA, Le Quan Sang KH, Imrich R, Rovensky J, Al-Sbou M, Ranganath LR, Santucci A.
Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project. Osteoarthritis Cartilage. 2018 Aug;26(8):1078-1086.
doi: 10.1016/j.joca.2018.05.017. Epub 2018 May 29. PMID: 29852277.
Penesová A, Dean Z, Kollár B, Havranová A, Imrich R, Vlček M, Rádiková Ž.
Nutritional intervention as an essential part of multiple sclerosis treatment? Physiol Res. 2018 Aug 16;67(4):521-533.
doi: 10.33549/physiolres.933694. Epub 2018 May 10. PMID: 29750884.
Masi AT, Imrich R, Cutolo M.
Hypothesis: Can Neuroendocrine Immune Testing in Individual Rheumatoid Arthritis Patients Guide the Benefits-To-Harms Ratio in Glucocorticoid Therapy? Comment on the Article by Palmowski et al. Arthritis Care Res (Hoboken). 2019 Apr;71(4):576-577.
doi: 10.1002/acr.23453. PMID: 29073334.
Vernerova L, Mravcova M, Paulikova L, Vlcek M, Marko A, Meskova M, Penesova A, Rovensky J, Wendl J, Raslova K, Vohnout B, Jochmanova I, Lazurova I, Killinger Z, Steiner G, Smolen J, Imrich R.
Contribution of Genetic Factors to Lower DHEAS in Patients with Rheumatoid Arthritis. Cell Mol Neurobiol. 2018 Jan;38(1):379-383.
doi: 10.1007/s10571-017-0522-0. Epub 2017 Jul 15. PMID: 28712091.
Vlcek M, Penesova A, Imrich R, Meskova M, Mravcova M, Grunnerova L, Garafova A, Sivakova M, Turcani P, Kollar B, Jezova D.
Autonomic Nervous System Response to Stressors in Newly Diagnosed Patients with Multiple Sclerosis. Cell Mol Neurobiol. 2018 Jan;38(1):363-370.
doi: 10.1007/s10571-017-0511-3. Epub 2017 Jun 21. PMID: 28639079.
