Lecture by Dr. Shambaditya Saha from the Institute of Molecular Biotechnology of the Austrian Academy of Sciennces, entitled „A role of complex composition in biomolecular condensates“ from the CAPSID Seminar Speaker Series, will take place on 12 November 2020 at 2 p.m. via online broadcasting via the ZOOM application.
We investigate a fundamental aspect of intracellular organization – compartmentalization independent of lipid membranes. Canonical cellular compartments are confined within lipid membranes, but recent discoveries suggest that a plethora of cellular compartments form independent of membrane boundaries by liquid-liquid phase separation. We aim to understand how these ‘liquid-like’ compartments assemble and carry out distinct cellular functions. Currently we are investigating how the non-membrane-bound ‘nuage’ organelle, conserved in the germline of sexually reproducing animals, contributes to germ cell fate and fertility. Research in our group is multi-disciplinary – combines biochemistry, biophysics, structural biology, in vitro reconstitution, and in vivo studies in C. elegans.
Our research will provide significant insights into two of the central questions in phase separation-dependent intracellular organization: 1) Rules that determine precise macromolecular composition i.e. specificity, and 2) Importance of phase separation for biological function. Phase separation has now been implicated in a wide range of fundamental biological processes and diseases – cellular DNA-damage response, RNA processing including transcription, splicing, translation and storage, biology of non-coding RNAs, signal transduction, T-cell activation, viral infection, neurodegeneration, and cancer. Therefore, the general principles about phase separation uncovered in our research will help with understanding the mechanisms of a wide range of vital biological processes.
More information about lecture and registration on the project web site: https://capsid.vbcf.ac.at/events/